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Principal Scientist, Peptide/Biomacromolecular Chemistry

Grove Biopharma, Inc.

Chicago, IL

Posted August 24

Job Description

Job Description:

Grove Biopharma is a breakthrough platform biotechnology startup, operating at the interface between materials science and biotherapeutics, pioneering the discovery and development of a new class of proteomimetic drug modality for challenging drug targets with the potential to address significant unmet medical needs in chronic inflammatory and neurodegenerative diseases.

We are looking for an energetic, motivated, principal research scientist to join our founding, multidisciplinary R&D team to lead the discovery of novel biomacromolecular therapeutics to treat human diseases. This peptide chemistry expert will be responsible for the design, synthesis, and analysis of peptide-based bioconjugates and macromolecules. The applicant will report to the CTO and will have close interactions with the executive team and collaborators. This role demands a highly goal-driven approach and the ability to focus on time-sensitive objectives to meet milestones. A demonstrated, deep understanding of peptide synthesis, synthetic chemistry, analytical chemistry, purification techniques, and processing technologies is critical.

Primary Responsibilities:

To advance discovery stage research projects through hands-on solid-phase synthesis of peptide bioconjugates and biomacromolecules
Oversee laboratory equipment (peptide synthesizer, LC-MS, preparative HPLC, SEC, etc.)
Effectively communicates and collaborates with other R&D team members to translate peptide-based biomacromolecular hits into lead compounds
Maintain accurate laboratory records, draft technical reports, and effectively communicate results to the executive team and external collaborators as required
Liaise with CROs
Influences the research pipeline by proposing new peptide research directions aligned with the company’s strategic agenda


PhD in organic chemistry, biochemistry, or related discipline preferred

Relevant required experience includes:

Strong synthetic skills including solid-phase peptide synthesis, organic synthesis, biomacromolecule purification and characterization, and biomolecular conjugation.

Strong experience in design and biochemical characterization of peptides and their bioconjugation chemistries
Structure-function based drug design knowledge and application for the optimization of peptide drug candidates
Strong skills in analytical LC-MS, preparative HPLC, and other analytical methods associated with the characterization of peptides, proteins, and biomacromolecular conjugates
Proven experiences in peptide/protein quantification, formulation, bioanalytical characterization, and stability testing
Strong interpersonal skills to be effective in an interdisciplinary cross functional discovery team
Strong written and oral communication skills
Legal authorization to work in the U.S


Experience with living polymerization methodologies (e.g. ring-opening metathesis polymerization)
A proven track record of accomplishment (peer-reviewed publications, conference talks, and patents) on polymer-biomolecule conjugates is desirable
A strong enthusiasm for innovation and ability to work collaboratively in a dynamic, fast-paced, multidisciplinary environment


Salary dependent on experience, performance bonus, equity incentive

Job Type: Full-time


Medical, Dental, and Vision insurance
Paid time off
State-of-the-art lab and office amenities, including 24h fitness center access

Grove Biopharma is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex, gender identity, sexual orientation, national origin, disability, protected veteran status or any other characteristic protected by local, state or federal laws, rules or regulations.

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